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SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.1
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
9
Vitamin D3 may reduce brain edema
Preoperative Serum Level of Vitamin D is a Possible Protective Factor for Peritumoral Brain Edema of Meningioma: A Cross Sectional Study.
High relevance to vitamin D3 effects
We investigated whether preoperative serum levels of vitamin D3 could influence peritumoral brain edema in patients diagnosed with meningioma. This study included 112 patients who underwent assessments of serum 25(OH)D levels and magnetic resonance imaging (MRI) to evaluate brain edema.
Our findings revealed a significant correlation between lower vitamin D3 levels and higher edema index (EI) percentages. Patients with EI below 100% had a median serum vitamin D3 level of 65.58 ng/mL, whereas those with EI above 100% had a much lower median of 37.33 ng/mL.
We found that for every increase of 1 ng/mL in serum vitamin D3, the extent of brain edema decreased by approximately 4%. This suggests that maintaining adequate levels of vitamin D3 may serve as a protective factor against peritumoral brain edema in patients with meningioma.
Our findings revealed a significant correlation between lower vitamin D3 levels and higher edema index (EI) percentages. Patients with EI below 100% had a median serum vitamin D3 level of 65.58 ng/mL, whereas those with EI above 100% had a much lower median of 37.33 ng/mL.
We found that for every increase of 1 ng/mL in serum vitamin D3, the extent of brain edema decreased by approximately 4%. This suggests that maintaining adequate levels of vitamin D3 may serve as a protective factor against peritumoral brain edema in patients with meningioma.
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8
Vitamin D3 and glioma cell senescence
Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells.
Direct impact on glioma treatment
We investigated the effects of 1,25-dihydroxyvitamin D3, the active form of vitamin D3, on glioma cells to understand its potential role in brain tumor treatment. Our study showed that this compound can induce cellular senescence, a state where cells stop dividing and can no longer contribute to tumor growth.
Specifically, we observed that vitamin D3 increased the levels of key senescence markers, INK4A and CDKN1A, suggesting that it effectively slows down the progression of glioma. Additionally, vitamin D3 upregulated KDM6B, a histone demethylase that plays a crucial role in promoting the expression of INK4A by altering the chemical modifications on chromatin that repress its transcription.
By knocking down KDM6B, we found that the senescence induced by vitamin D3 was reduced, indicating that KDM6B is essential for this process. Overall, our findings reveal a new mechanism by which vitamin D3 could help inhibit the growth of glioma, paving the way for future prevention and treatment strategies.
Specifically, we observed that vitamin D3 increased the levels of key senescence markers, INK4A and CDKN1A, suggesting that it effectively slows down the progression of glioma. Additionally, vitamin D3 upregulated KDM6B, a histone demethylase that plays a crucial role in promoting the expression of INK4A by altering the chemical modifications on chromatin that repress its transcription.
By knocking down KDM6B, we found that the senescence induced by vitamin D3 was reduced, indicating that KDM6B is essential for this process. Overall, our findings reveal a new mechanism by which vitamin D3 could help inhibit the growth of glioma, paving the way for future prevention and treatment strategies.
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8
Vitamin D3 enhances surgery recovery
Single high-dose vitamin D3 injection and clinical outcomes in brain tumor resection: A randomized, controlled clinical trial.
Strong relevance to treatment effects
We evaluated the potential benefits of a high-dose vitamin D3 injection on patients with low vitamin D levels undergoing surgery for brain tumors. In our study, 60 patients with benign brain tumors and a serum level of 25-hydroxyvitamin D (25(OH)D) of 20 ng/mL or less were randomly divided into two equal groups.
The study group received a single injection of 300,000 IU of vitamin D3 before their craniotomy, while the control group did not receive any intervention. Following the surgery, we observed that the vitamin D3 treatment resulted in a significant increase in serum vitamin D levels for those in the study group.
Moreover, this boost in vitamin D was linked to better clinical outcomes. Specifically, patients who received the vitamin D3 injection experienced shorter stays in the Intensive Care Unit (ICU) and overall hospitalization compared to those who did not.
However, it's important to note that while we saw reductions in ICU and hospital stay lengths, there were no significant differences in the rates of perioperative complications between the two groups. Overall, our findings suggest that administering high doses of vitamin D3 is safe and can lead to improved recovery times for patients undergoing brain tumor surgery.
The study group received a single injection of 300,000 IU of vitamin D3 before their craniotomy, while the control group did not receive any intervention. Following the surgery, we observed that the vitamin D3 treatment resulted in a significant increase in serum vitamin D levels for those in the study group.
Moreover, this boost in vitamin D was linked to better clinical outcomes. Specifically, patients who received the vitamin D3 injection experienced shorter stays in the Intensive Care Unit (ICU) and overall hospitalization compared to those who did not.
However, it's important to note that while we saw reductions in ICU and hospital stay lengths, there were no significant differences in the rates of perioperative complications between the two groups. Overall, our findings suggest that administering high doses of vitamin D3 is safe and can lead to improved recovery times for patients undergoing brain tumor surgery.
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Most Useful Reviews
8.8
Tumour reduction
This vitamin D3 was recommended by my doctor for my immunity. I also gave some to my father, who has a brain tumour and required a high potency dose. It has actually reduced his tumour slightly and improved his health levels! So it certainly works.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.1
9
Vitamin D3 shows promise against glioblastoma
Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases Their Susceptibility to Temozolomide.
Moderately relevant combination findings
We explored the potential of calcitriol, the active form of vitamin D, in treating glioblastoma, one of the most aggressive brain tumors. Our research aimed to see if vitamin D could target the stem-like cells that contribute to tumor growth and resistance to treatment.
Through a combination of lab tests, including real-time PCR and organ transplant cultures, we found that calcitriol can effectively reduce the stem-like properties of glioblastoma stem cells. Interestingly, it also worked well alongside Temozolomide, a common chemotherapy drug, helping to improve its effectiveness. In some cases, the combination completely eliminated the tumor cells we analyzed.
These promising results suggest that calcitriol could serve as an important part of treatment for certain patients with glioblastoma. However, further studies will be essential to fully understand its potential and optimize its use in clinical settings.
Through a combination of lab tests, including real-time PCR and organ transplant cultures, we found that calcitriol can effectively reduce the stem-like properties of glioblastoma stem cells. Interestingly, it also worked well alongside Temozolomide, a common chemotherapy drug, helping to improve its effectiveness. In some cases, the combination completely eliminated the tumor cells we analyzed.
These promising results suggest that calcitriol could serve as an important part of treatment for certain patients with glioblastoma. However, further studies will be essential to fully understand its potential and optimize its use in clinical settings.
Read More
9
Vitamin D3 may reduce brain edema
Preoperative Serum Level of Vitamin D is a Possible Protective Factor for Peritumoral Brain Edema of Meningioma: A Cross Sectional Study.
High relevance to vitamin D3 effects
We investigated whether preoperative serum levels of vitamin D3 could influence peritumoral brain edema in patients diagnosed with meningioma. This study included 112 patients who underwent assessments of serum 25(OH)D levels and magnetic resonance imaging (MRI) to evaluate brain edema.
Our findings revealed a significant correlation between lower vitamin D3 levels and higher edema index (EI) percentages. Patients with EI below 100% had a median serum vitamin D3 level of 65.58 ng/mL, whereas those with EI above 100% had a much lower median of 37.33 ng/mL.
We found that for every increase of 1 ng/mL in serum vitamin D3, the extent of brain edema decreased by approximately 4%. This suggests that maintaining adequate levels of vitamin D3 may serve as a protective factor against peritumoral brain edema in patients with meningioma.
Our findings revealed a significant correlation between lower vitamin D3 levels and higher edema index (EI) percentages. Patients with EI below 100% had a median serum vitamin D3 level of 65.58 ng/mL, whereas those with EI above 100% had a much lower median of 37.33 ng/mL.
We found that for every increase of 1 ng/mL in serum vitamin D3, the extent of brain edema decreased by approximately 4%. This suggests that maintaining adequate levels of vitamin D3 may serve as a protective factor against peritumoral brain edema in patients with meningioma.
Read More
9
Vitamin D analogs inhibit glioblastoma
Vitamin D Analogues Tacalcitol and Calcipotriol Inhibit Proliferation and Migration of T98G Human Glioblastoma Cells.
Relevant to brain tumor treatment
We investigated how synthetic analogs of vitamin D, specifically tacalcitol and calcipotriol, impact the growth and movement of T98G human glioblastoma cells. This type of brain cancer is particularly aggressive and challenging to treat, making it vital to explore new therapeutic options.
Our findings revealed that both vitamin D analogs significantly decreased cell viability and reduced the rate at which these cancer cells proliferated. This was evident in our tests, where even low concentrations of the analogs, ranging from 1 nM to 10 μM, showed a notable suppression of cell growth.
We also conducted a wound-healing assay to assess the migration of T98G cells. Both tacalcitol and calcipotriol were effective in slowing down the movement of these cells compared to a control group. Interestingly, even though we saw these promising effects, the analogs did not appear to trigger apoptosis, as measured by caspase-3 and -7 activities.
Overall, our research supports the potential of vitamin D analogs as a promising avenue for the treatment of glioblastoma by significantly inhibiting both the growth and migration of cancer cells.
Our findings revealed that both vitamin D analogs significantly decreased cell viability and reduced the rate at which these cancer cells proliferated. This was evident in our tests, where even low concentrations of the analogs, ranging from 1 nM to 10 μM, showed a notable suppression of cell growth.
We also conducted a wound-healing assay to assess the migration of T98G cells. Both tacalcitol and calcipotriol were effective in slowing down the movement of these cells compared to a control group. Interestingly, even though we saw these promising effects, the analogs did not appear to trigger apoptosis, as measured by caspase-3 and -7 activities.
Overall, our research supports the potential of vitamin D analogs as a promising avenue for the treatment of glioblastoma by significantly inhibiting both the growth and migration of cancer cells.
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8
Vitamin D3 shows glioblastoma potential
Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells.
Strong relevance to treatment effectiveness
We explored the potential of calcitriol, the active form of vitamin D, as a treatment for glioblastoma, an aggressive form of brain cancer. Our research involved testing over 40 different glioblastoma cell cultures to determine how these cells respond to vitamin D3.
Interestingly, we found that about half of the cell lines were sensitive to calcitriol's effects, with a quarter showing particularly strong responses. These high responders appeared to exhibit changes in their protein makeup that suggested a reduction in traits associated with stemness and migration, which are commonly linked to tumor aggressiveness.
Additionally, we identified that certain genetic variations of the vitamin D receptor could help predict which cells would respond positively to treatment. Overall, the findings hint that vitamin D3 could play a role as a viable therapeutic option for some glioblastoma patients, though further research is necessary to confirm these benefits comprehensively.
Interestingly, we found that about half of the cell lines were sensitive to calcitriol's effects, with a quarter showing particularly strong responses. These high responders appeared to exhibit changes in their protein makeup that suggested a reduction in traits associated with stemness and migration, which are commonly linked to tumor aggressiveness.
Additionally, we identified that certain genetic variations of the vitamin D receptor could help predict which cells would respond positively to treatment. Overall, the findings hint that vitamin D3 could play a role as a viable therapeutic option for some glioblastoma patients, though further research is necessary to confirm these benefits comprehensively.
Read More
8
Vitamin D3 may aid survival
Optimal vitamin D status at admission appears to improve survival after craniotomy in patients with brain malignancies.
Significant vitamin D3 relevance observed
We explored the impact of vitamin D3 treatment on patients with brain tumors who underwent craniotomy—a surgical procedure commonly used to treat malignancies in the brain. Our study included 56 patients divided into three groups: one that received a substantial dose of vitamin D3, another that did not receive any vitamin D3 treatment, and a third group that had optimal vitamin D levels at the time of admission.
We observed that the group with optimal vitamin D status had significantly higher preoperative levels of vitamin D compared to the other groups. Moreover, their survival rates were noticeably better, suggesting there may be a connection between sufficient vitamin D levels and improved outcomes after surgery. Interestingly, despite the positive results in the initial analysis, we noted that this association weakened when factoring in other variables in more detailed models.
Additionally, factors like age and total calcium levels were also identified as important in predicting mortality rates in this group. Overall, while the findings point toward the potential benefits of maintaining optimal vitamin D levels for brain tumor patients undergoing surgery, further research is necessary to fully understand the implications of vitamin D on survival outcomes.
We observed that the group with optimal vitamin D status had significantly higher preoperative levels of vitamin D compared to the other groups. Moreover, their survival rates were noticeably better, suggesting there may be a connection between sufficient vitamin D levels and improved outcomes after surgery. Interestingly, despite the positive results in the initial analysis, we noted that this association weakened when factoring in other variables in more detailed models.
Additionally, factors like age and total calcium levels were also identified as important in predicting mortality rates in this group. Overall, while the findings point toward the potential benefits of maintaining optimal vitamin D levels for brain tumor patients undergoing surgery, further research is necessary to fully understand the implications of vitamin D on survival outcomes.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Tumour reduction
This vitamin D3 was recommended by my doctor for my immunity. I also gave some to my father, who has a brain tumour and required a high potency dose. It has actually reduced his tumour slightly and improved his health levels! So it certainly works.
